Wellness and Anti-aging Applications
Wellness and Anti-aging Applications
What is Phenotypic Age and How is It Calculated?
The rate at which a person ages has a significant impact on that person's risk of chronic disease. Therefore, measuring a person's aging rate using some observable characteristics can be an effective way to prevent chronic diseases that may occur in the future.
A new measure of aging based on laboratory markers that can be measured routinely to see a person's aging rate and current physiological age. phenotypic age developed. This measurement was developed by a group of scientists from UCLA by examining a total of 11,432 people aged between 20 and 84, and determines how old people are biologically and physiologically. In short, your phenotypic age tells you how old you are biologically compared to your chronological age.
Chronological age alone is a very strong predictor of death risk. Every person is born, grows, grows old and dies. In this case, the probability of people dying as they get older is increasing. However, when we add the person's attention to health, lifestyle and genetic heritage to this equation, in addition to their chronological age, we can also measure individual differences. Blood tests used in calculating phenotypic age allow us to take these individual differences into account. In order to calculate the phenotypic age, the following parameters are used in addition to the person's chronological age:
AlbuminAlbumin helps transport many small molecules through the blood, including some drugs and hormones. It plays an important role in preventing fluid in the blood from remaining in the vessel and leaking into the tissues.
creatinine: Serum creatinine level is a test used as a measure of the kidneys' ability to filter blood. As the level of crenin increases, it becomes clear that the kidneys cannot function properly.
fasting blood sugar: Fasting blood sugar is the measurement of glucose level in the blood measured without consuming any food within 8 hours. High sugar is considered an indicator of pre-diabetes and diabetes. Uncontrolled elevation of sugar levels results in chronic inflammation in the body and long-term tissue and organ damage.
CRP: C-reactive protein is a protein produced by the liver against inflammation and inflammation in the body. It is known to increase in viral and bacterial infections, as well as in certain chronic diseases. An increase in CRP is perceived as the presence of a process that is not going well in terms of health in the body.
Lymphocyte percentage: Lymphocytes, one of the white blood cells, are the most important cells of our immune system. These cells often play an active role in viral infections. A high lymphocyte count may be a sign of viral infection or chronic inflammation. High lymphocyte count is observed especially in autoimmune diseases.
Mean cell volume (MCV): A measurement that shows the average size of red cells. Small size of red blood cells is observed in cases of thalassemia carrier and iron deficiency anemia. A high MCV may indicate B12 and folic acid deficiency, pernicious anemia and liver disorders.
Red cell distribution width (RDW): This blood test shows us the size difference between red cells. If the red cells are very close in size, the RDW will be low. If the dimensional differences between red cells are high, then the RDW will be high. It is a test used as a measure of anemia, parallel to the MCV test.
alkaline phosphatase: Alkaline phosphatase, also known as ALP, is an enzyme produced by various organs of the body. It is found mostly in the liver, bones, kidneys and digestive system. Elevated ALP levels usually indicate that there may be a problem in the above organs. Although low ALP level is a very rare condition, it can be observed in cases of malnutrition, zinc deficiency and thyroid disorders.
White blood cell count (WBC): White cells are cells that fight infection in our body. Rising white blood cell count indicates that there may be an active infection in our body. It is also observed that the level increases in allergies and rheumatic diseases. Low white blood cell count may indicate autoimmune diseases, bone marrow-related problems and some cancers.
The higher a person's phenotypic age is compared to their chronological age, the higher their health-related risks will be.